Rubén Francés Selected Research

Norfloxacin

1/2020	Liver Sinusoidal Endothelial Cells Contribute to Hepatic Antigen-Presenting Cell Function and Th17 Expansion in Cirrhosis.
1/2018	Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis.
12/2016	Selective intestinal decontamination with norfloxacin enhances a regulatory T cell-mediated inflammatory control mechanism in cirrhosis.
11/2015	Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis.
1/2015	Use of proton pump inhibitors decrease cellular oxidative burst in patients with decompensated cirrhosis.
10/2014	Role of interleukin 10 in norfloxacin prevention of luminal free endotoxin translocation in mice with cirrhosis.
3/2011	Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis.
11/2009	Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis.
3/2008	Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis.
7/2007	Bacterial DNA induces the complement system activation in serum and ascitic fluid from patients with advanced cirrhosis.

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Rubén Francés Research Topics

Disease

45	Fibrosis (Cirrhosis) 01/2021 - 07/2002
15	Ascites 10/2019 - 07/2002
14	Inflammation (Inflammations) 01/2021 - 01/2011
9	Peritonitis 01/2020 - 12/2002
8	Crohn Disease (Crohn's Disease) 03/2022 - 08/2011
6	Liver Diseases (Liver Disease) 01/2020 - 02/2013
5	Bacterial Infections (Bacterial Infection) 01/2018 - 12/2002
5	Infections 10/2014 - 06/2004
5	Necrosis 02/2014 - 06/2004
4	Melanoma (Melanoma, Malignant) 02/2022 - 01/2015
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021 - 01/2018
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2021 - 02/2014
2	Obesity 01/2021 - 01/2020
2	Non-alcoholic Fatty Liver Disease 01/2020 - 01/2020
2	Endotoxemia 10/2019 - 09/2011
2	Portal Hypertension 10/2019 - 08/2019
2	Hepatic Encephalopathy 10/2019 - 01/2017
1	Ulcerative Colitis 11/2021
1	Ileal Diseases 01/2021
1	Hidradenitis Suppurativa 03/2020
1	Colonic Polyps 01/2020
1	Polyps 01/2020
1	End Stage Liver Disease 10/2019
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Hepatitis 01/2018
1	Alcoholic Fatty Liver 01/2018
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2018
1	Disease Progression 05/2017
1	Pancreatitis 05/2017
1	Sudden Infant Death (SID) 12/2016
1	Psoriasis (Pustulosis Palmaris et Plantaris) 06/2015
1	Insulin Resistance 07/2014
1	Weight Loss (Weight Reduction) 07/2014

Drug/Important Bio-Agent (IBA)

26	Bacterial DNAIBA 03/2020 - 07/2002
15	CytokinesIBA 01/2020 - 12/2002
11	Norfloxacin FDA Link 01/2020 - 09/2006
6	Interleukin-6 (Interleukin 6)IBA 01/2020 - 06/2004
6	Carbon Tetrachloride (Tetrachloromethane)IBA 12/2018 - 12/2010
5	Bacterial AntigensIBA 01/2021 - 07/2014
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 09/2006
5	EndotoxinsIBA 10/2014 - 07/2007
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2010 - 12/2002
4	InflammasomesIBA 02/2022 - 01/2015
4	Anti-Bacterial Agents (Antibiotics)IBA 11/2015 - 03/2008
3	Biological ProductsIBA 03/2022 - 09/2006
3	AlbuminsIBA 01/2021 - 12/2018
3	Interleukin-10 (Interleukin 10)IBA 01/2019 - 01/2011
2	beta Adrenergic ReceptorsIBA 09/2020 - 01/2012
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2020
2	C-Reactive ProteinIBA 01/2020 - 01/2019
2	Butyrates (Butyrate)IBA 10/2019 - 01/2011
2	Pharmaceutical PreparationsIBA 01/2019 - 04/2013
2	Interleukin-18 (Interleukin 18)IBA 05/2017 - 01/2015
2	AntigensIBA 01/2017 - 02/2016
2	Phenobarbital (Luminal)FDA Link 02/2016 - 10/2014
1	ChemokinesIBA 03/2022
1	Ustekinumab (CNTO 1275)FDA Link 11/2021
1	BilirubinIBA 01/2021
1	nasIBA 01/2021
1	Dietary Fiber FDA Link 01/2021
1	bisphenol AIBA 01/2021
1	CarbonIBA 01/2021
1	CatecholaminesIBA 09/2020
1	Adrenergic Agents (Adrenergic Drugs)IBA 09/2020
1	Adrenergic Receptors (Adrenergic Receptor)IBA 09/2020
1	Interleukin-4 (Interleukin 4)IBA 01/2020
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	Interleukin-2 (IL2)IBA 01/2020
1	Interleukin-17 (Interleukin 17)IBA 01/2020
1	Interleukin-23 (Interleukin 23)IBA 01/2020
1	Butyric Acid (Butanoic Acid)IBA 10/2019
1	Simvastatin (Zocor)FDA LinkGeneric 08/2019
1	Adalimumab (Humira)FDA Link 01/2019
1	Infliximab (Remicade)FDA Link 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2019
1	Volatile Fatty AcidsIBA 12/2018
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 12/2018
1	NLR ProteinsIBA 12/2018
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2018
1	interleukin 20 (IL-20)IBA 01/2018
1	MicroRNAs (MicroRNA)IBA 01/2018
1	Rifaximin (L 105)FDA Link 01/2018
1	Interleukin-22 (IL-22)IBA 01/2018
1	Messenger RNA (mRNA)IBA 05/2017
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017
1	Lactulose (Duphalac)FDA LinkGeneric 01/2017
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2016
1	Proton Pump InhibitorsIBA 01/2015
1	SodiumIBA 11/2014
1	NucleotidesIBA 02/2014
1	p38 Mitogen-Activated Protein KinasesIBA 04/2013

Therapy/Procedure

4	Liver Transplantation 01/2021 - 01/2018
3	Therapeutics 07/2015 - 01/2013
2	Ligation 01/2020 - 10/2014
2	Oral Administration 06/2019 - 01/2018
1	Immunomodulation 01/2020
1	Surgical Portasystemic Shunt (Portosystemic Shunt) 10/2019
1	Biological Therapy 02/2014